The survivors return to the city to find it burning: it is assumed that the city is engulfed with zombies. After returning to their armored car, the blood sample is destroyed when one of the soldiers detonates a hand grenade. The second time around works, leaving only two of them alive. The operatives are unsuccessful in the initial attempt to gain a sample.

Despite her survival, it is indicated she transformed and murdered Rudy Curien (Jonathan Cherry), her ex-boyfriend and another survivor from the first movie. Eventually the operatives discover that the original hypersapien is Alicia (Ona Grauer), from the previous House of the Dead film. Battles rage from the library, to the dorm rooms, to the football fields.

The parties now face an army of highly evolved zombies that can easily chew through their body armor. Outside parties, interested in financially exploiting the zombies, also cause, second-hand, further conflict. The operatives must bring back a first-generation blood sample from a zombie in order to create a vaccine against the virus, which is spread through biting however, tensions between AMS and special forces, stemming from the apparent inexperience of the latter, create conflict within the team. Taking place shortly after the original, government operatives under the command of one of the survivors of the first film, Colonel Jordan Casper (Ellie Cornell), are sent to investigate a new infection that has rapidly spread across fictional Cuesta Verde University.

House of the dead 2 (2005)